Minomic Announces Completion of Accrual for Clinical Study of Miltuximab® in Prostate, Bladder and Pancreatic Cancers

No Drug-Related Adverse Effects Found in Patients
( | Press Release | 2018-07-30 10:40:16 )
Sydney, Australia, 24th July 2018: Minomic International Ltd (Minomic) is an immuno-oncology company specializing in therapeutics and diagnostics for solid tumors, including prostate, bladder and pancreas. The Company today announced that it has completed enrolment and dosing of all 12 patients in its pioneering clinical trial of Miltuximab®, a chimeric version of Minomic’s MIL-38 anti-Glypican 1 antibody conjugated to the radioactive isotope 67Gallium.

The Miltuximab® Trial is a first-in-human study to evaluate the safety and tumor targeting of Miltuximab®, in patients with metastatic prostate, bladder, and pancreatic cancer. The primary endpoint of the MILGa trial is safety and tolerability of Miltuximab®. Secondary endpoints include tumor targeting, pharmacokinetics and dosimetry to determine relative accumulation of Miltuximab®, in different organs.

All patients have now been dosed and we are pleased to report Miltuximab® was well tolerated with patients reporting no drug related adverse events. Secondary endpoints will be reported when data analysis is completed - to date these are progressing well.

Minomic’s CEO, Dr Brad Walsh, said, “These results will inform the future development of the drug and most importantly the next step, progression to a Phase 1 trial in Australia. Each phase in this process enhances the attractiveness of the company to potential partners. ”
We are grateful to the principal investigator Prof. Howard Gurney and his team at Macquarie University Hospital for their dedication to bringing new therapies to cancer patients.

About Minomic
Minomic International Ltd is an Australian immuno-oncology company specialising in therapeutics and diagnostics for solid tumors, including prostate, bladder and pancreas. Miltuximab® is a first-in-class treatment for certain solid tumours that can address the growing immuno-oncology market for cancer treatment (currently a US$51B market). Results for Minomic’s first-in-human trial for Miltuximab® have demonstrated great promise in cancer targeting combined with an excellent safety profile. Commercialization of this exciting and specific technology is enhanced by a strong propriety position around the target, called Glypican-1, which has been shown to be present in a number of different solid tumours including , prostate, pancreatic, bladder, oesophageal, brain and ovarian cancers. Minomic is interested in partnerships or collaborations with larger pharmaceutical/diagnostic global partners able to produce, register and distribute Miltuximab®.

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